Wolves 0 - 1 Tottenham Hotspur
L
 22/08/2021 (Premier League)
Nottingham Forest 0 - 4 Wolves
W
 24/08/2021 (LC)
Wolves 0 - 1 Manchester United
L
 29/08/2021 (Premier League)
Watford 0 - 2 Wolves
W
 11/09/2021 (Premier League)
Wolves 0 - 2 Brentford
L
 18/09/2021 (Premier League)
Wolves 2 - 2 Tottenham Hotspur
L
 22/09/2021 (LC)
Southampton 0 - 1 Wolves
W
 26/09/2021 (Premier League)
Wolves 2 - 1 Newcastle United
W
 02/10/2021 (Premier League)
Aston Villa 2 - 3 Wolves
W
 16/10/2021 (Premier League)
Leeds United 1 - 1 Wolves
D
 23/10/2021 (Premier League)
Wolves 2 - 1 Everton
W
 01/11/2021 (Premier League)
Crystal Palace 2 - 0 Wolves
L
 06/11/2021 (Premier League)
Wolves 1 - 0 West Ham United
W
 20/11/2021 (Premier League)
Norwich City 0 - 0 Wolves
D
 27/11/2021 (Premier League)
Wolves vs Burnley 30/11/2021 (Premier League)
Wolves vs Liverpool 04/12/2021 (Premier League)
Manchester City vs Wolves 11/12/2021 (Premier League)
Brighton & Hove Albion vs Wolves 14/12/2021 (Premier League)